Evidence Based Detoxification: Fasting Mimicking Diet & Supplements To Avoid During Detox!

broccoli

 What is a fasting mimicking diet? It is a low carb – low protein (calorie deficit) diet that you do for 4-5 days out of the month (not a way of life and not meant to be eaten forever). It is not just ANY foods you consume. It has to be foods that are going to safely facilitate the removal of chemicals/xenobiotics/metals that are sequestered in your tissues.5

Why would someone want to do a FMD? When used as part of detoxification protocol, it has been proven in scientific literature to reverse irritable bowel disease, intestinal inflammation, remove heavy xenobiotic exposure, reverse diabetes/impaired pancreatic beta cells or hepatic steatosis.5

FMD’s vs Water Fasting: A 2019 study found that FMD’s were more beneficial in reducing intestinal inflammation, increased stem cell number, stimulated protective gut microbiota, and reversed IBD related intestinal pathology, whereas water-only fasting increased regenerative and reduced inflammatory markers without reversing pathology.3

What would a FMD look like? The Journal of Cancer Epidemiol Biomarkers Prev. found that a specific combination of veggies was able to increase glutathione s transferase. GST is a protein that enables xenobiotics to be removed from our body.4 The study found 4.5 cups of cruciferous veggies: (0.5 cups radish sprouts, 1 cup cauliflower, 2 cups broccoli, 1 cup cabbage). And 3 TBSP fresh chives, 1.33 cups of leeks, 1 tsp garlic, 0.5 cups onion – to facilitate the removal of xenobiotics and drastically help the liver out with detoxing.4

 

Assess Your Toxin Load with QEESI.org: You can’t manage what you don’t measure!QEESI

 

 

How Can I Make This Into A FMD?: Two 4-5 modified FMD’s per month consisting of the following is successful in assisting with detoxification4,6:

5 cups cruciferous/brassica veggies

½ onion, 3 cloves garlic, 1 leek

1-2 TBSP fat/oil

Honeybush tea, Dandelion root tea, or rooibos tea (this has no caffeine)6

30 min exercise followed by 30 min sauna (does not matter the kind of sauna)

Supportive Supplements: There are some choice supplements to take, and I will not list all or doses, but some noteworthy ones are:  Activated charcoal and/or GI Detox. Even Modified Citrus Pectin. Interestingly enough, St. John’s Wort was found to be helpful in the removal of xenobiotics. St. John’s Wort stimulates this compound called P-glycoprotein (Pgp) that is responsible for systemic disposal of numerous structurally and pharmacologically unrelated drugs, carcinogens, toxins, and other xenobiotics in many organs, such as the intestine, liver, kidney, and brain. Like cytochrome P450s, Pgp is vulnerable to inhibition, activation by herbs.2

 

DISCOVERYA New Phase of Liver Detox Discovered: It is well known of Phase 1 and Phase 2 of liver detoxification. In 1992 “Phase 3” was discovered. Now, within the last 5 years it has been discovered that there is a “Phase 0.”1

Metabolism in the liver represents a coordinated sequence of enzymatic steps: (1) extraction of compounds from the portal blood is followed by uptake into a liver cell (phase 0). (2) oxygenation/activation of compounds (phase I); (3) glucuronidation or sulfation, acetylation, methylation or conjugation to glutathione (phase II); and (4) secretion/excretion (phase III).1

Going back to what was said above about “Pgp” being responsible for disposal of numerous drugs, carcinogens, and xenobiotics in many organs, Pgp is a part of Phase III detox pathway. In the Journal of Drug Metabolism, it was observed that curcumin in supplement form, black pepper, and SOME green tea catechins, milk thistle inhibited Pgp.2

Snap shot of a research article

Are Curcumin, Milk Thistle and Green Tea Extracts Beneficial for Detox? This was a hard pill to swallow, most of the liver detox formulas on the market contain green tea, milk thistle and curcumin.  One particular study in the Journal of Drug Metabolism found that black pepper, curcumin (in supplement form, not spice form) and milk thistle down-regulated different Phases of Liver Detox.

compound and molecular target table

There are also several fruits and vegetables that down-regulate liver enzymes, but I’m not suggesting we don’t eat fruits and vegetables. That is absurd! I’m suggesting perhaps these mega doses of certain supplements should be looked at more carefully. And at different points of peoples lives with different states of health or unhealth, certain doses of things may be required. Pluto was a planet when I was a kid, then it wasn’t a planet. Now it’s being reconsidered as a planet lol. Science is always changing.

 

The Journal of Nutrition Metabolism:

Many foods appear to act as both inducers and inhibitors of CYP1 (Phase 1 Detox) enzymes, an effect which may be dose dependent or altered by the isolation of bioactive compounds derived from food. Curcumin at 0.1% of the diet has been shown, in animals, to induce CYP1A1, yet a diet of 1% turmeric was inhibitory . Black tea at 54 mL/d induced both CYP1A1 and 1A2, yet 20 mg/kg of theaflavins was inhibitory to CYP1A. Soybean intake at 100 mg/kg upregulated CYP1A1 activity, yet at 1 g/kg black soybean extract and 200 mg daidzein twice daily, its effect was inhibitory. Further research is needed to confirm different dose effects and impact in humans.” – (Hodges & Minich, 2015)

Side note: Upon searching for these articles, I found this one ^ and Dr. Minich is one of my amazing professors at the Uni where I’m acquiring my Masters Degree in Functional Medicine. (I may or may not have fan girled out when I saw her name on this study).

 

 

 

References:

  1. Döring, B., & Petzinger, E. (2014). Phase 0 and phase III transport in various organs: Combined concept of phases in xenobiotic transport and metabolism. Drug Metabolism Reviews,46(3), 261-282. doi:10.3109/03602532.2014.882353
  2. Zhou, S., Lim, L., & Chowbay, B. (2004). Herbal Modulation of P‐Glycoprotein. Drug Metabolism Reviews,57-104. Retrieved from https://www.tandfonline.com/doi/abs/10.1081/DMR-120028427.
  3. Rangan, P., Choi, I., Wei, M., Navarrete, G., Guen, E., Brandhorst, S., . . . Longo, V. D. (2019). Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Reports,26(10). doi:10.1016/j.celrep.2019.02.019
  4. Steinkellner, H., Hietsch, G., Sreerama, L., Haidinger, G., Gsur, A., Kundi, M., & Knasmüller, S. (2000). Induction of Glutathione-S-Transferases in Humans by Vegetable Diets. Dietary Anticarcinogens and Antimutagens,193-198. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/10952095.
  5. Wei, S., Han, R., Zhao, J., Wang, S., Huang, M., Wang, Y., & Chen, Y. (2018). Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice. Nutrition & Metabolism,15(1). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245873/.
  6. Hodges, R. E., & Minich, D. M. (2015). Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. Journal of Nutrition and Metabolism,2015, 1-23. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488002/.

Author: Melissa Mullin

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