The Healthy Melissa's Blog

My journey into the world of Health,Wellness, and Functional Medicine

Category: Epigenetics

The ACTN3 Gene: What Kind of Exercise Is Most Suited For YOUR BODY To Lose Weight?

Genetic testing is becoming more popular through websites such as 23andme. You spit in a vial and send it off, 8 weeks later – your entire genome is interpreted for you; showing you more about yourself than ever was able before.

Functional Medicine is all about getting to the root of the disease. I strongly agree that 1 size does not fit all in terms of treatment. But what happens when you are able to fine tailor a persons medical treatment right down to their genes?

I attended an amazing lecture on Stress, Genetics and how it effects Metabolism, with Dr. Penny Kendall-Reed, ND as the key speaker. Her clinical work with genetic testing has all the more confirmed that every single person requires more specified treatment. Right down to the type of exercise that they do!

The ACTN3 Gene: 

  • “Contains instructions for making the alpha-actinin-3 protein, which is found in fast twitch muscle fibers. Some people have a variant in the ACTN3 gene that causes them not to make any alpha-actin-3 protein. Almost all elite power athletes who have been studied have this genetic variant that allows them to produce this protein.” – 23andme.com

My Results:  I have done the 23andme genetic test, and I found out that I do not have ACTN3, a gene that encodes for the production of actin protein in fast twitch muscle fibers.

The Significance: Therefore I am an unlikely sprinter (thanks mom and dad) side note: Interestingly enough, both my parents did the test too. My father (a runner and former body builder) has 1 ACTN3 gene and my mother has none (my mom can’t run for crap). Higher odds are that I was going to not have the ACTN3 genes available to me.

Demographics For Prevalence Of ACTN3 Gene:

CC = 2 copies of the ACTN3 gene (which makes you a very fast elite athlete)

CT = 1 copy of ACTN3 gene and 1 non-copy (still fast)

TT = 2 non-copies of the ACTN3 gene (an unlikely sprinter and not as fast)

What This Translates To In Terms Of Exercise:

Because of this low/nonexistent actin protein, Dr. Kendall-Reed explains: “High Intensity Interval Training is not as beneficial for those with low actin protein. High Intensity Interval Training type exercises are more inflammatory, and can often make the person feel ‘bigger’ instead of slimming down.”  Instead, she states”exercises that are lighter in weight with higher repetitions – and longer/slower endurance exercises are more beneficial.” Dr. Kendall-Reed says that although she shares the same non-existent ACTN3 gene, she still does sprints – she does them for longer durations and spaces them out over the course of a week, instead of doing them every day.

My personal experience: I used to do more “Sprint 8” / HIIT exercises and didn’t feel it worked very well. I didn’t notice a rapid change in my body composition. More recently, these past two months I’ve been doing more resistance training/weight lifting and I’ve noticed a humongous change in my body composition in all the right ways. (makes total sense).

If you want to order a test kit, here is the link: 23andme !

If You Have Already Done The Genetic Test:

  1. Go to 23andme.com and sign in
  2. Click on “Reports”
  3. Click on “Wellness Reports”
  4. Click on “Muscle Composition”
  5. You will find your results in there.

 

 

 

Sources: 

23andme.com

all pictures are directly from 23andme.com

 

 

 

 

 

 

 

 

 

Diabetes Of The Brain: Are You At Risk?

Cog Impairmenet

How would you feel if I looked into a crystal ball and told you that you were definitely going to develop Alzheimer’s Disease or Dementia? You would forget your loved ones, you’d forget who YOU are, and you would have your license taken away, your right to be independent, and have to resort to taking a bunch of medication every day to slow down your dying brain, all of this while you lay in a hospital bed? Not a great fortune to be told, right?

How would you feel if I told you that you have complete control of that by stopping the amount of sugar you are consuming every day?

Alzheimer’s Disease is being classified as Diabetes of The Brain or Diabetes Type 3. Did you realize that?

Your pancreas is an organ that puts out a hormone called Insulin. Every time you eat sugar, whether it be a banana, mango, bread, alcohol, pasta, piece of candy – WHATEVER, your pancreas secretes insulin to grab the sugar and store it away in your liver for energy, in your muscles – and then as FAT if you are not using the sugar.

What insulin also does is it patrols the tau protein and plaque in your brain. Insulin degrades these plaque/proteins that build up in the brain. When you are constantly eating sugar everyday, not exercising to burn off the excess sugar, the proteins and plaque go unchecked! They build and build and then BOOM your memory suffers, and you develop Alzheimer’s or Dementia.

Alz Brain

One teaspoon of sugar is equivalent to 4 grams. This is a good piece of information to keep in mind when you’re purchasing pre-packaged foods or drinks/teas/juices. If you’re eating a ton of sugar every single day, if you are a gluten junkie, if you’re eating tons of bread, pasta, cereals, rice every single day – look into that crystal ball my friend. What ever you do now echos in eternity. Just like whatever you eat now, will echo in your life as an older adult.

I was at a seminar on Brain Chemistry in February this year, and the speaker told me the average onset of Alzheimers Disease he sees in his clinic is 51 years old. So in 25 years, I could be suffering from full blown Alzheimer’s? That’s insane! That means that whatever I do right now is going to determine me getting that disease in 25 years.

What you can do:

downloadExercise: burn the excess sugar off. Sugar is inflammatory. High intensity Interval Training such as “Tabata Exercises” are the best exercise that oxygenates the brain and most efficiently helps the body in 4 minutes (who doesn’t have 4 minutes?).

 

download
Eat lots of fruits and vegetables (berries and apples are the lower glycemic ones).
Blueberries & black berries are amazing for improving cognitive function

carnitex-60c
-Take Acetyl L-Carnitine to support mitochondrial health, brain function and protects neuronal function.

 

 

 

 

dl202028Take Anti-inflammatory agents: such as Curcumin, Reseveratrol every day – your brain is inflammed if you have an form of cognitive impairment or neurological degeneration. The ideal curcumin to take is one that crosses the blood brain barrier. Curcumin and Resveratrol quell inflammation on a cellular level by inhibiting the inflammatory cascade caused by NF-kB. Once this becomes turned on, it is a self feeding loop of                 inflammation, but with those two anti-inflammatory agents, it is dampened.

 

omegapure-900-ec-90c_083115EPA/DHA – Those with cognitive impairment supplemented with Omega 3 Fatty Acids and demonstrated less neuronal loss and improved cognitive function.

-Do something different every day, don’t stop doing math problems, drive a different way home, learn an instrument, do cross word puzzles, create new pathways in the brain to keep your mind sharp.

Most importantly: stop eating wheat/gluten and dairy. These two foods have been proven in a multitude of studies to alter your brain and gut. The proteins from wheat and dairy cross react with the cerebellum (the part of the brain responsible for coordination and balance).

 

You should always speak with your functional medicine practitioner or PCP before beginning any supplements to ensure that they do not interact with any medications that you are on.

-Have a healthy day-

The Mold Gene: HLA-DRB1

moldy

I am a strong believer in epi-genetics.

Epi-genetics is the scientifically proven theory that your genes do not determine your health, but your environment is what determines whether a disease causing gene will express itself. Example: Because your mom had breast cancer, it does not mean that you are destined to breast cancer. If you eat no fruits and vegetables, live a high stress life style, use all plastic containers and drink from plastic water bottles, and don’t ever exercise – then you will be switching on your predisposition to breast cancer.

Environmental Factors Are:

  1. Development in utero and childhood
  2. Internal dialogue/thoughts you think on a daily basis
  3. What foods you eat
  4. Environmental chemicals that you are exposed to
  5. Drugs and medications that you take
  6. Methylation has been strongly linked to being able to activate or repress a gene. Methylation is part of phase 2 of liver detox where you utilize B vitamins and Folate to pull toxins out of your body so that you can excrete them. If you have a genetic weakness (such as the MTHFR) in that pathway of methylation, then you need to be taking methylated B vitamins to assist your body in detoxification and energy production.

Genetics are like the loaded gun, and the environment is what pulls the trigger. If you maintain a healthy environment , the trigger never gets pulled.

 

What Is The HLA-BRB1 Gene?

The HLA-DRB1 gene provides instructions for making a protein that plays an important role in how the immune system functions. The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body’s own proteins from proteins made by foreign invaders such as viruses and bacteria.

In approximately 24% of the population, there is a mutation in this gene that causes even the smallest exposure to a biotoxin to wreak absolute havoc on a person’s immune system. These people cannot handle the environmental exposure to mold and they switch on the faulty gene & express symptoms rather quickly.

What This Means For You:

There are multiple kinds of variations in this gene, and based on which one you have it can express itself in the following ways:

  • Mild susceptibility to extreme susceptibility to being sick from mold exposure
  • More likelihood of contracting Chronic Lyme Disease/inability to fight it off
  • Susceptibility of being sick from ingesting Dinoflagellates (fish)
  • MARCoNS (A nasty nasal infection/sinusitis)
  • Low MSH
  • Developing Multiple Sclerosis
  • Developing Chronic Fatigue
  • Developing Chronic Fatigue from Lyme vaccine Lymerix – It will cause an inflammatory immune response in certain genotypes. In another genotype is worked well.
  • There are MAJOR contraindications from the Gardasil Vaccine for cervical cancers and should be avoided based on what variation of this gene you have.

If you already have one or more of these conditions, you definitely need to do the genetic test to find out what is going on inside your body on a cellular level and then take further steps to rid your body of these toxins and boost your immune system.

How To Test If You Have The Genetic Mutation In This Gene:

It is a simple blood test that you can have your doctor do. A lot of times doctors will say you don’t need it or they will not do it because they adhere to what the insurance companies deem appropriate to test for, which is wrong! Your doctor works for YOU. If you want a test done, you should be able to have it done. Individual insurances will vary so it’s best to call them and ask them if that is something you can do through insurance. If you do not have insurance or do not want to use insurance you can always go through Professional Co-op. They offer significantly discounted prices for lab testing. Life-Extension is another lab that does this test, but Professional Co-op is less expensive. Functional Medicine Practitioners will more than likely do this test for you.

What You Can Do To Detox Mold & Biotoxins From Your Body:

charcoal

Activated Charcoal – This acts as a sponge and soaks up everything, allowing you to excrete toxins out through the bowels. In one study that looked at subjects who were fed deoxynivalenol (which is a mycotoxin that occurs in grains) and then given activated charcoal. The results were that after ingestion of charcoal there was no mycotoxin that could be detected in the blood.

 

NAC-60c_042115N-Acetyl Cysteine & Glutathione – NAC is an amino acid that converts into the master antioxidant Glutathione. Glutathione has a short half life, so if you can do both at the same time it will increase the circulation in your body longer. This combo is very useful in binding heavy metals, candida, toxins and detoxing the liver. In one case study of a woman who accidentally ingested toxic mushroom, she was treated with activated charcoal, NAC and after only 10 days she was healed and had no organ complications.

chlorella

Chlorella – This is a green algae that has been shown to cleanse your intestines, bind to mold toxins and heavy metals and eliminate them through the bowels. It also cleanses the liver and the blood. Clean blood assures that metabolic waste will get carried away from your tissues. Chlorella also allows your body to process more oxygen (which lowers cancer risk). Studies conducted in Japan have evidenced that chlorella may also help reduce body fat, and help with weight related diabetes, lower cholesterol and high blood pressure.

Another 3 year study conducted with 350 people who worked in a metal facility, were given chlorella to remove very toxic heavy metals: Mercury, Antimony, Lead, Cadmium and Arsenic. The results showed those who took chlorella had removed ALL heavy metal completely. –Note: Chlorella contains iron, so it is important for men to have their iron and ferritin levels checked. Women have their periods so it usually is not an issue for them

cilantro

Cilantro – Cilantro is a green herb that also has a detoxification effect. It works with mold toxins and heavy metals.

As Dr. Mercola states, “You should always start any detox with chlorella gradually, taking just a small amount at first to see how your body tolerates this powerful detoxification tool. Some people also report benefits from beginning a detoxification by first eating small amounts of cilantro for a few days. Cilantro also promotes a detoxification response in your body, but at a less intense level — which may help your body ease into a smoother detoxification response from chlorella.”

waterrrExercise  & Drink Water – Toxins normally are sequestered in body fat. One of the best ways to remove stored toxins is to exercise! But also be sure to drink plenty of water. When you lose weight and don’t drink enough water, it will cause your toxins to flood the body because now there is less space for them to be stored, and more toxins all at once. It is VERY important that you drink at least half your body weight in ounces of pure water every day (and especially if you are detoxing).

All supplements and testing mentioned here are available at Dr. Jack’s Wellness Center.

 

Sources:

https://ghr.nlm.nih.gov/gene/HLA-DRB1#conditions

http://www.ncbi.nlm.nih.gov/pubmed/26091874

https://ghr.nlm.nih.gov/gene/HLA-DRB1#conditions

http://www.ncbi.nlm.nih.gov/pubmed/25337799

http://www.ncbi.nlm.nih.gov/pubmed/12762072

http://www.ncbi.nlm.nih.gov/pubmed/6202479

http://www.ncbi.nlm.nih.gov/pubmed/19950279

Pictures Courtesy of:

https://www.xymogen.com/assets/imageDisplay.ashx?productID=129&attachmentTypeID=2&imageID=435

forestcountypublichealth.org

Chlorella Powder

http://everythingessential.com/essential-oils/

www.bulletproofexec.com

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